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Hormonal Changes: Pregnancy : Hormonal changes during pregnancy can cause melasma or the mask of pregnancy leading to symmetrical dark patches on the face

Histology pictures were acquired on a KeyenceBZ-9000 microscope (Keyence)

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Much more research in humans is needed

AEs leading to trial product discontinuation occurred in 51/603 (8.5%) participants in the CagriSema 2.4 mg/2.4 mg group, 40/605 (6.6%) participants in the semaglutide 2.4 mg group, 7/152 (4.6%) participants in the cagrilintide 2.4 mg group, 42/594 (7.1%) participants in the CagriSema 1 mg/1 mg group, 26/608 (4.3%) participants in the semaglutide 1 mg group, and 2/149 (1.3%) participants in the placebo group

Treatments usually last between 30 minutes to an hour, during which patients may relax or engage in light activities such as reading or listening to music