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Pause, assess, recalculate, and resume only when the cause is identified

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Creatinine is produced at a constant rate and can be used to normalize the concentrations of other analytes

Similarly, the ELF score, which combines serum markers of matrix turnover including hyaluronic acid, procollagen type III n-terminal peptide (PIIINP), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) has been validated for fibrosis staging and is currently recommended by several guidelines [79, 80]

The choice depends on muscle mass and the doctors preference

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