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Sustained elevation of IGF-1 is associated, in observational studies of acromegaly (a disease of GH excess), with increased risk of several cancers including colorectal and breast

doi: 10.1016/s1473-3099(23)00692-8 89 DerayG

Cell Metabol 34:19471959 e5 Chen SG, Stribinskis V, Rane MJ, Demuth DR, Gozal E, Roberts AM, Jagadapillai R, Liu R, Choe K, Shivakumar B (2016) Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged Fischer 344 rats and Caenorhabditis elegans

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Observational studies in humans being treated for other conditions have noted incidental reductions in alcohol use or related outcomes among patients receiving GLP-1 receptor agonists (Quddos et al