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(12 March 2023)

Moreover, CKD serves as a risk factor for cardiovascular disease, infections, strokes and other life-threatening conditions, underscoring its status as a global disease burden [4,5,6]

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During OXPHOS, electron leakage from the electron transport chain leads to the generation of ROS, which can markedly increase under conditions of mitochondrial dysfunction [152]

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These fibrillar aggregates are comprised of a peptide or protein, specific to a certain disease 16, 17