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At Primary Care of Clear Lake, we understand that starting a new medication like Zepbound for weight loss can come with a period of adjustment
However, natural human GLP-1 has a very short half-lifeit is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4), lasting only a few minutes in the bloodstream
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Gastroenterology (2015) 149:38997.e10
Read in context, it is a secondary, exploratory outcome from a Phase 2 trial whose primary endpoint, change in cerebral glucose metabolism, was negative, and whose cognitive signal was modest
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