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An elevated methylmalonic acid (MMA) level has been thought to be the most direct, metabolic indicator of B12 deficiency because B12 is the only cofactor required by the enzyme that degrades MMA

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GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Among the top 50 hits (proteins most enriched by LaccID in TCR-T cell coculture versus monoculture) were 33 proteins with direct literature links to CD8 + T cell activation, another 3 proteins with indirect links, 2 membrane proteases (ADAM19 and FURIN) and 8 mitochondrial proteins (Fig

These factors may lead to hyperactive neurological responses, releasing a cascade of signals that alter cerebral blood vessel dynamics and neurotransmitter levels, such as serotonin and CGRP, leading to the inflammation and pain characteristic of a migraine