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And and least in those who stay on the treatment forever So what happens when you discontinue the drugs
What the FDA Requires in the BLA Efficacy Data: TRIUMPH-4: 28.7% weight loss Complete TRIUMPH-1: 28.3% weight loss Complete TRIUMPH-2: 20.8% weight loss (obesity + diabetes) Complete TRIUMPH-3: 22.6% weight loss (obesity + cardiovascular disease) Complete, MACE data not statistically significant Safety Data: Side effect profile across all four populations Short-term and medium-term adverse events, including the dysesthesia signal (up to 20.9% at 12mg) Drug interactions, especially with diabetes medications Manufacturing Data: Scale-up capability for millions of doses per month Quality control and stability data Cold chain distribution logistics Realistic Approval Scenarios With the BLA filing point now expected (Q1 2027), the remaining uncertainty is largely in the FDA review itself not in whether or when Lilly files
To address these concerns and sustain the progress made, many healthcare providers recommend transitioning to a maintenance dose rather than discontinuing treatment altogether
Mild side effects like nausea or fatigue can appear but usually fade as the body adjusts
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The Growth Hormone Reality Peptides like CJC-1295 and Ipamorelin do increase growth hormone and IGF-1 levels
