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The intervention modulated the structure of obesity-associated gut microbiota, enriching beneficial taxa such as Bifidobacterium and Lactobacillus , and elevated levels of microbial metabolites, notably butyrate

Entre las manifestaciones multisistmicas, destacan: derrame pericrdico, episodios stroke-like por aumento de la agregacin plaquetaria, tubulopata proximal, hipogonadismo, retinopata pigmentaria, osteopenia y hepatopata

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264 Therapeutic targeting of the UPR and ERAD in cancer IRE1 inhibitors UPR signaling and ERAD are critical adaptive pathways that allow cancer cells to survive chronic ER stress

Treatment frequency varies based on individual goals and initial consultation recommendations