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and improved performance on memory tests compared with placebo

The benefits of SGLT2i therapy also extends to CKD where there is a significantly reduced risk of decline in eGFR and progression to end stage renal failure, regardless of presence or absence of type 2 diabetes [23]

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Semaglutide reduces cardiovascular risk independent of weight loss , with similar cardiovascular benefits observed in patients who did not lose weight compared to those who did

Understanding these patterns helps researchers predict outcomes and select appropriate candidates for study protocols

The glucagon receptor component drives energy expenditure and hepatic fat mobilisation, a mechanism absent in earlier-generation incretin compounds