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Gallbladder and biliary tract events have been reported with GLP-1-based therapies, primarily related to gallstones
doi: 10.1186/1743-422X-9-295 23 GullnerG.KomivesT.GborjnyiR
These effects were subsequently managed through slower absorption kinetics, extended dosing intervals, and careful titration, allowing therapeutic benefit to outweigh adverse events ( 5.1 Peptide YY and the misinterpretation of early tolerability signals Peptide YY (PYY) is secreted postprandially by enteroendocrine L cells and functions as a satiety hormone by activating Y2 receptors in the hypothalamus and brainstem, where it inhibits neuropeptide Ymediated orexigenic signaling ( However, subsequent clinical trials reported high rates of nausea and vomiting, leading to the perception that PYY-based therapies were intrinsically intolerable
That is why GLP-1 drugs for heart protection in autoimmune disease now attract attention
10.1016/j.bbi.2020.10.014 98 SunH.ShuJ.TangJ.LiY.QiuJ.DingZ.et al (2024)
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