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For patients who are not well-controlled on a treatment with metformin and basal insulin, a treatment intensification with a DPP-4 inhibitor may be feasible

Pola P, Tondi P, Dal Lago A, and et al

PubMed Duzel, A., Vlainic, J., Antunovic, M., Malekinusic, D., Vrdoljak, B., Samara, M., Gojkovic, S., Krezic, I., Vidovic, T., Bilic, Z., Sjekavica, I., Djuzel, A.R., Knezevic, M., Sever, A.Z., Lojo, N., Kokot, A., Sever, M., Drmic, D., Seiwerth, S., & Sikiric, P

First, it has direct anti-inflammatory effects, addressing pain at its source rather than simply masking symptoms

(4) Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ