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This is an inherited genetic disease called pyroglutamic aciduria which manifests as hemolytic anemia and metabolic acidosis, causing neurological disorders and vulnerability to bacterial infections, and which can be classified as mild, moderate or severe depending on the severity of the symptoms
Preservatives such as metacresol or phenol may be included to prevent bacterial and fungal contamination during multiple-use vials, though single-use formulations may contain no preservatives at all
NIDDK Meal Timing Article [8] National Heart, Lung, and Blood Institute