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The involvement of the -catenin signaling in the Ex-4-induced improvement in hepatic steatosis was suggested previously by Seo and coworkers 37 who showed that the -catenin inhibitor IWR-1 abrogates the protective effect of Ex-4 against palmitate-induced steatosis
For AEA, Danan Ds study (132) showed that AEA levels (in hippocampus) were significantly reduced under long-term stress (1 week after PSS)
European Journal of Endocrinology, 139(5), 552-561
Khalifeh 2009
Animal reproduction studies suggest potential risk, though human data is absent
Tirzepatide holds both signals on for a week, allowing the drug to reach appetite centers and metabolic tissues that a short meal signal barely reaches. The two signals are not balanced
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