First described by Novo Nordisk researchers, ipamorelin is notable for its selectivity in stimulating growth hormone release without significantly affecting other pituitary hormones such as ACTH, prolactin, FSH, LH, or TSH in preclinical models
Kuang F, Liu J, Li C, Kang R, Tang D
Lund Toxicology Reports.2026
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Subsequent investigational work explored ghrelin-receptor agonists like ipamorelin for conditions such as postoperative ileus, but ipamorelin never reached an approved marketed indication