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1,949 adults with severe obesity (BMI 35) and established cardiovascular disease, with or without type 2 diabetes, randomized 1:1:2 to retatrutide 9mg, 12mg, or placebo over 80 weeks

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With subsequent costs expected to skyrocket (the market may hit $471 billion by 2032!), employers need a clear strategy to manage this billion-dollar trend and the growing impact on pharmacy benefits plans

Cause-specific mortality could not be independently adjudicated, and the precise timing of death relative to semaglutide initiation could not be systematically determined due to the absence of consistently recorded death dates in the structured dataset

For 0.2 mg dose, draw 0.8 units on insulin syringe