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In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)
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Glutathione/glutathione disulfide (GSH/GSSG) ratio and Nicotinamide adenine dinucleotide phosphate NADPH/NADP+ ratio were measured using GSH/GSSG Assay Kit (S0053, Beyotime) and NADP/NADPH Quantification Kit (S0179, Beyotime) respectively
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Treatments with Glutathione IV: Infusions typically last 20 to 30 minutes and are administered biweekly or every week in clinical environments
Regulation of tumor necrosis factor (TNF)-alpha synthesis and TNF receptors expression in T lymphocytes through the CD2 activation pathway
