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The anti-aging and skin rejuvenation research protocols from clinical literature use 1mg daily as a starting point, with 2mg daily for accelerated protocols or those specifically targeting tissue repair during active fat loss

However, individual response varies based on genetic factors in GIPR, FTO, and MC4R pathways

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JAMA 325(14):14141425 Garvey WT, Batterham RL, Bhatta M et al (2022) Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

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