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DOI: Published online: October 15, 2025 1 Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan 3 Kurinami Clinic, Kanzaki, Kumamoto, Japan 4 Division of Cardiovascular Medicine, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 5 Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan Corresponding author: Hideaki Jinnouchi

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Conclusion: In this report, we have characterized the EV proteome from supernatants of primary human hepatocytes, human liver organoids, and blood samples of patients with NASH allowing for the identification of novel cell-type specific and disease-related biomarkers

This variation is expected

It provides a highly effective, clinically viable alternative that bypasses hepatic first-pass metabolism, specifically designed to maximize adherence

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