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Key Takeaways Wegovy Pill (oral semaglutide, 25 mg, Novo Nordisk) was FDA-approved for weight loss on December 22nd, 2025 with the medication expected to be available to patients in early January 2026
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Treatments are normally about 1 week apart
One area that has attracted academic discussion, press coverage, and significant biotechnology/pharma R&D investment is concern about undesirable, collateral skeletal muscle mass (SMM) loss, and presumably by extension, loss of strength and function in people taking GLP-1 medications
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Glucagon receptor activation supports hepatic glucose handling during fasting states
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