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The concentrations achieved in vitro evidently exceeds what is achieved with oral administration, particularly for compounds with limited bioavailability, extensive metabolism, and broad tissue distribution
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Nephrol Dialysis Transplantation 27(4):13511358 Evans M, Lewis RD, Morgan AR, Whyte MB, Hanif W, Bain SC et al (2022) A narrative review of CKDin clinical practice: current challenges and future perspectives
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