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Based on Phase 2 trial protocols, the standard approach looks like this: Weeks 1 to 4: 1 mg once weekly Weeks 5 to 8: 2 mg once weekly Weeks 9 to 12: 4 mg once weekly Weeks 13 to 16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (if tolerated) That is a minimum 16 to 20 week ramp-up to reach the maximum dose, compared to a similar timeline for Ozempic

Dement Geriatric Cogn Disorders Extra 6(2):295302 Ali NH et al (2024a) Neprilysin inhibitors and risk of Alzheimers disease: a future perspective

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NP scope is the single biggest cross-state variable

Pernicious anaemia (an autoimmune condition affecting B12 absorption) is a common cause of B12 deficiency that requires specific testing for anti-intrinsic factor antibodies

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