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Management of metabolic comorbiditiesincluding diabetes, hypertension, and dyslipidemiais essential, as these conditions both contribute to and result from MASLD

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Genetic Variations : Specific Genetic Mutations Certain genetic mutations predispose the patients to a higher risk of developing vitiligo

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity