Ronald Kahn & team show glutathione depletion in the liver surprisingly prevents fatty liver disease by selectively oxidizing certain proteins involved in fat production, rather than causing broad damage
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The randomized and placebo-controlled design of all included trials and the double-blind design of most of them can also be other strengths and due to the RCT nature of the studies, the drugs used by the patients (especially in diabetic patients), the diet and the level of physical activity of the participants were controlled and in fact their effects were considered and it can be said that the pure effects of L-carnitine was evaluated
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While no large trial has tested creatine specifically in GLP-1 users, the mechanism is relevant: creatine improves training performance, and better training performance means more muscle stimulus during a deficit
Several mechanisms help explain the observed increase in gallbladder events during GLP-1 therapy