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The cardiovascular outcome trials for the new obesity pharmacotherapies will help us understand better the long-term benefits and risks with each molecule

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It is responsible for recycling tetrahydrobiopterin (BH4), a critical cofactor required by the eNOS enzyme

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Cbl acts as a cofactor for two pivotal metabolic enzymes in humans: cytosolic methionine synthase (MeSe) and mitochondrial methylmalonyl-CoA mutase (MMUT)