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However, when tau proteins are hyperphosphorylated, it has been suggested that they may produce microtubule destabilization, synaptic injury and neurodegeneration (Lerchundi et al., 2011)

[ CrossRef ] [ Google scholar ] [ PubMed ] Zhou XM, Wang GL, Wang XB, Liu L, Zhang Q, Yin Y, et al

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Interestingly, through these structural optimizations, compounds 27 and 28 were obtained as the highest-affinity compounds

References Tesamorelin LiverTox: Clinical and Research Information on Drug-Induced Liver Injury National Institutes of Health, NIDDK (2018) Tesamorelin (Subcutaneous route) Drug Information Mayo Clinic / IBM Merative (2025) Effects of tesamorelin (TH9507), a growth hormonereleasing factor analog, in HIV-infected patients with excess abdominal fat: a pooled analysis of two phase 3 trials J