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doi: 10.1080/19490976.2022.2117508 119 PedersenHKGudmundsdottirVNielsenHBHyotylainenTNielsenTJensenBAHet al

Discontinuation rates in trials range from 2040% due to tolerability issues, making this medication challenging for sensitive individuals

However, it is unlikely to cause damage to the liver overall

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In addition, the studies differ in duration, dose escalation, participant characteristics, number-based estimands, and whether the drug was used alone or in combination