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Because no official human dosing study exists
Decreased appetite: This is partly the point, but can become problematic if caloric intake drops too low for too long
human evidence remains preliminary and observational
In particular dietary resistant starch has been shown in studies to upregulate GLP-1 and PYY (Peptide YY, a hormone that can decrease appetite) in a sustained manner
5EG), and the expression of CBS (Fig
After GLP-1 initiation, individuals with higher exercise volumes showed a smaller increase in minimum heart rate at very high exercise levels, suggesting fitness helps buffer the HR response
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