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Interruptions and Discontinuation Increase Cardiovascular Risk Moreover, longer discontinuation was progressively associated with elevated MACE risk, with IRRs of 1.14 for one year of discontinuation and 1.22 for two years

DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss

GLP-1 receptor agonists such as Ozempic are currently in demand, not just for effective loss but also for glucose management

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doi: 10.3945/jn.113.188599

Ashraf W, Park F, Lof J, Quigley EM