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While bimagrumab has shown promise as a safe pharmacological intervention for enhancing muscle mass and reducing fat mass in sarcopenia, its minimal effects on muscle strength and broader physical performance to date have introduced a note of caution

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We overcome this by triangulating our conclusions and recommendations based on the findings from multiple studies and the consistent oral vitamin B12 dosage of 1000 g

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GPR40 may be coupled with the -subunit of the Gq family of G proteins (Gq) and activates phospholipase C (PLC) (Fig