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The variability in ADCs design may render differences in their pharmacokinetics (PK) and pharmacodynamics (PD)

Accessed at pubmed.ncbi.nlm.nih.gov/26132939

In a Phase 3 clinical trial Orforglipron demonstrated superior glycaemic control compared with Dapagliflozin, with a tolerability profile consistent with the GLP-1 receptor agonist class, including increased rates of discontinuation due to adverse events, positioning it as a potential effective oral treatment option for type 2 diabetes

doi: 10.1158/0008-5472.CAN-23-0323 72 Di TanoMRaucciFVernieriCCaffaIBuonoRFantiMet al

Use fats strategically Healthy fats are most useful when they support a meal instead of dominating it

B., Panuwet, P., Nguyen, J