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Some patients report that microdosing can help manage side effects, reduce costs or maintain weight loss, but evidence on these approaches remains limited

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Heart rate monitoring may be warranted given the glucagon component mild chronotropic effects

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Because rapid weight regain also stresses the biliary system, steady nutrition and activity are important during transitions

For PCA analysis, all metabolites were used following quantile-normalization in the Statistical Analysis module of MetaboAnalyst 6.0