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The risk of birth defects is especially sensitive to factors during early pregnancy, and here blood glucose plays a vital part. A clear correlation The study demonstrates a clear correlation between elevated levels of blood glucose (HbA1c) in the mother and the risk of heart defects in her baby

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Wegovy Regret, Stopping, and Restarting: What Real Users and Clinical Trials Actually Show At a glance Drug / semaglutide 2.4 mg (Wegovy), weekly subcutaneous injection Weight regain after stopping / ~two-thirds of lost weight returns within 12 months (STEP-4 withdrawal data) Average weight loss on treatment / 14.9% body weight at 68 weeks in STEP-1 (N=1,961) Restart titration / always begin at 0.25 mg/week regardless of prior dose Most common regret trigger / GI side effects, cost (~$1,300/month without insurance), and inadequate response Re-titration schedule / 4 weeks per dose level (same as initial prescribing label) Discontinuation rate in STEP-1 / 7.3% semaglutide arm vs

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Through rigorous synthesis and analysis of available data, we aimed to provide valuable insights into the safety profile of GLP-1 RAs in this distinct patient population

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