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Emerging evidence suggests that treatment with the dual GLP-1 and GIP receptor agonist, tirzepatide, might prove even more potent than a GLP-1RA alone, to ameliorate NAFLD

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IGF-1 LR3 is a modified analog of human Insulin-Like Growth Factor-1, engineered with two structural changes an arginine substitution and a 13-amino acid N-terminal extension that reduce its binding to IGF-1 binding proteins

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Comparing the two, tirzepatide sometimes brings more intense GI effects, especially at higher doses