In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required
It is not appropriate for individuals to obtain, reconstitute, or self-administer this compound outside of such settings
All doses markedly suppressed food intake compared to vehicle controls, with the 30 and 300 nmol/kg doses producing the strongest anorectic effects, reducing 24-hour food intake by 51% and 57%, respectively
Tahir, Y
Other Regenerative Peptides Beyond BPC-157 and TB-500, there are several other peptides used in regenerative protocols
WhatsApp AXIOM Reading Useful companion pages include GHK-Cu vs BPC-157 and the repair and matrix cluster