This analysis also indicated that sitagliptin was the only DPP-4 inhibitor that improved insulin resistance when used as monotherapy
In contract, overt hepatic encephalopathy can present with disorientation, obvious personality change, inappropriate behavior, somnolence, stupor, confusion, and coma (106)
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GLP-1 and GIP receptor agonists (the dual mechanism in tirzepatide) act on the central nervous system to suppress appetite
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Clinical studies consistently show substantial weight loss outcomes in patients using GLP-1 medications, often accompanied by improvements in blood sugar control, cholesterol levels, and decreased cardiovascular risks