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International Journal of Molecular Sciences, 18 (12), 2589
GLP-1RAs, including semaglutide, liraglutide, and tirzepatide, are currently FDA approved for the treatment of obesity in patients with a body mass index (BMI) greater than or equal to 30 or a BMI greater than or equal to 27 in the setting of an obesity-related comorbidity, including asthma
Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis
A meta-analysis that included data from 11 randomized controlled trials with a combined total of 483 women with PCOS found that vitamin D, at doses ranging from 4,0007,143 IUs (100179 mcg) per day, resulted in lower total testosterone, insulin resistance, total cholesterol, and low-density lipoprotein (LDL)-cholesterol
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QT assay sensitivity was demonstrated with moxifloxacin as positive control (placebo-adjusted QTcF change from baseline was above 5 msec at all pre-defined time points)
