Clinicians should proactively recheck thiopurine metabolites within four to six weeks of starting a GLP-1RA to prevent unexpected toxicity
A uniquely positioned Canadian market Novo Nordisk's data exclusivity for semaglutide expired in Canada on January 4, 2026, following a lapse in key Canadian patent protection tied to a maintenance-fee issue
Patients should contact their GP or prescribing clinician if they experience: Severe or persistent abdominal pain , particularly in the upper right quadrant or radiating to the back, which could indicate biliary complications such as bile duct stones or pancreatitis Persistent vomiting that prevents adequate fluid or medication intake, risking dehydration Signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst Jaundice (yellowing of skin or eyes), which may suggest bile duct obstruction Severe diarrhoea lasting more than 48 hours or accompanied by blood Unexplained fever with abdominal symptoms Pancreatitis is a rare but serious potential side effect of GLP-1 receptor agonists
The question is whether the field is willing to slow down long enough to ask what its missing
Available at: Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D
It is especially important for energy and fat metabolism