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Improves overall skin appearance: The combination of collagen stimulation, anti-inflammatory action, and wound-healing support produces broad improvements in skin quality

FXR1 depletion further enhanced this synergy, resulting in a much enhanced sensitivity to tamoxifen (Figure 7D

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Without these clinical confirmations, the administration of polyphenols for therapeutic applications becomes challenging, as there is a lack of clear indications regarding their efficacy, optimal intake, and specific pathologies in which they can be utilized [161]

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