Based on Phase 2 clinical trials, patients with T2DM who were inadequately managed with diet and exercise alone or were on a stable metformin regimen for at least 3 months before screening received once-weekly subcutaneous injections of tirzepatide at doses of 1 mg, 5 mg, 10 mg, or 15 mg for 26 weeks
Briefly, ARPE-19 cells were seeded into 96-well plates (5 10 3 /well), and incubated overnight
It is a triple hormone receptor agonist on the GLP-1, GIP, and glucagon receptors
The experiment was performed in the presence and absence of CellTox Green Dye to determine if the fluorescent dye had an effect on the subsequent luminescent signal of the GSH/GSSG-Glo Assay
2018;26:931 Li Y, Tian H, Zeng H, Zhang Y, Yin T, He H, et al
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