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The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

Contraindications include Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera

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a larger Intramuscular (in the muscle) 25 gauge 1 inch needle for maximum intramuscular benefit, a shorter 25 gauge 5/8 inch, and a smaller Deep Subcutaneous (under skin) 29 gauge 1/2 inch needle

Bacteriostatic Water is avoided in neonates because the benzyl alcohol preservative can be toxic to infants

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