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In patients with chronic renal disease, GLP-1 receptor agonists are increasingly recommended because of their cardiovascular and kidney-protective effects and can be used across a broad range of renal function
It may help to increase the breakdown of fat in the body and improve the use of fat as an energy source
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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity
We have not made it a mandatory program
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
