While hGH did produce a slight increase in glycerol in the knockout mice, the response was markedly lower than in WT animals
Studies have shown that the bioavailability of B12 is three times greater in dairy products than in fish, poultry, and meat
IGF-2 can act over its own receptor (IGF-2 receptorIGF-2R), which is a manose-6-phosphate transmembrane protein with undetermined actionsit is thought that it acts as a scavenger receptor by sequestering IGF-2 and IGF-1 from the extracellular medium and targeting them for destruction [103]
Our bodies however are only able to absorb 2g of vitamin B12 per meal, therefore additional supplementation may be beneficial
[2] However, once stores are depleted, symptoms can include fatigue, weakness, constipation, loss of appetite, and neurological changes such as numbness, tingling, balance problems, and cognitive difficulties
Reference: Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ (2024)