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Seek emergency care for difficulty breathing, facial swelling, chest pain, or severe allergic reactions

By inhibiting the NP (natriuretic peptide) system, sacubitril/valsartan increases natriuretic peptides (NPs) levels that, in turn, lead to vasodilation, natriuresis and RAAS inhibition through intracellular cyclic guanosine monophosphate (cGMP)-dependent pathways

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Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgzolu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, Mrz W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN (2015) Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

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