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Early agents such as hexamethonium were the first effective antihypertensives, demonstrating that pharmacologic reduction of blood pressure could prevent cardiac complications (left panel)

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Cornelissen, 2018)

The human body obtains glutathione in two ways: some is produced internally, while some is provided by the diet

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In contrast, the subjects of clinical trials are complex patient populations, particularly elderly individuals with comorbid sarcopenia, obesity, or multiple metabolic diseases, whose muscle metabolic foundation is more fragile [63]