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Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S, et al
The authors interpreted the data as supporting NNMT inhibition as a candidate exercise-mimetic
That could change after the committee review in July 2026, but today, it's not approved
Oral bioavailability studies in rats show systemic effects even when administered per os, suggesting meaningful absorption through the GI mucosa
Rare risks involve hormonal fluctuations, temporary mood dips if doses are too high, or interactions with SSRIs and MAOIs, which can amplify serotonin effects
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