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NEJM Flint A, et al

Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the obesity paradox

It has several physiological effects, such as modification of heart rate, blood pressure, pain threshold and some lymphokine system functions

Najt, C

Summary of the findings The current article evaluated 13 studies, of which eight were randomized clinical trials comparing different administration routes of vitamin B12 in patients with vitamin B12 deficiency