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Proglucagon processing in a rat islet cell line resembles phenotype of intestine rather than pancreas
At very high oral doses (54 mg), gastrointestinal side effects increased significantly
Some patients find that remaining at a lower maintenance dose, whilst potentially sacrificing some glycaemic or weight loss benefits, provides an acceptable balance between efficacy and tolerability
The headline numbers from the phase 2 obesity trial were striking: the highest dose group averaged 24.2% body weight reduction at 48 weeks, far ahead of what any single-mechanism drug had managed
Studies indicate the average 40- to 49-year-old woman needs to lose ~30 lbs to reach a BMI of 25, the upper limit of what is considered a healthy weight range
The food noise was silenced, which has been the most refreshing thing
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