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The pattern across all four disease areas is consistent: the groups with the highest documented disease incidence, prevalence, or mortality are the same groups most underrepresented in the trials generating the evidence base for treating that disease, a structural mismatch that FDA's own guidance explicitly names as the policy rationale for the Diversity Action Plan requirement ( [85] )

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In this genus, the relative abundance of the vehicle-treated group transitioned from WD to LD was significantly higher than both the lean and obese control groups

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