Abbreviations AA: Amino acid [Ca 2+ ] i : Cytoplasmic free Ca 2+ concentration DPP-4: Dipeptidyl peptidase 4 EGFP: Enhanced green fluorescent protein GCGR: Glucagon receptor GLP-1: Glucagon-like peptide 1 GLP-1R: GLP-1 receptor GPCR: G protein-coupled receptor GRA: Glucagon receptor antagonist IC 50 : Half-maximal inhibitory concentration NPY: Neuropeptide Y PKA: Protein kinase A PPPG: Preproglucagon promoter P/Q-type Ca 2+ channel: Voltage-gated Ca 2+ channel sensitive to -agatoxin PTX: Pertussis toxin TIRF (microscopy): Total internal reflection fluorescence (microscopy) VGCC: Voltage-gated calcium channel References Cryer PE (2015) Hypoglycemia-associated autonomic failure in diabetes: maladaptive, adaptive, or both
Documented protocols describe starting at 20 mcg for the first 2-3 days to assess tolerance, then increasing to 50 mcg if well-tolerated
The First 24 to 72 Hours Most people notice the onset of nausea within the first day of their first injection
High obesity rates statewide
Burping is normal, but sometimes it can smell like sulfur (rotten egg smell), which is embarrassing and unpleasant
It just gets it." "Everything in one place: protein tracking, water, injections, weight chart