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Graphical Abstract Keywords Drug hepatotoxicity, Acetaminophen, Lipid peroxidation, Oxidative stress, Ferroptosis, Glutathione peroxidase 4, Erastin, Ferrostatin-1, Methotrexate, Rifampicin, Isoniazid, Natural products Introduction Drug-induced liver injury (DILI) is a significant clinical problem worldwide

A peptide is a short chain of amino acidsessentially a fragment of a protein

The inflammatory response in myocardial injury, repair, and remodelling

You should avoid eating grapefruit or drinking grapefruit juice

What you're left with isn't a weaker version of the original compoundit's a string of amino acids that no longer binds to receptors